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The regulatory mechanism mediated by the endoplasmic reticulum affecting levels of polyunsaturated fatty acids The endoplasmic reticulum is the primary center for lipid metabolism within the cell, responsible for lipid desaturation, phospholipid synthesis, remodeling, and the biosynthesis of lipid droplets

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Positive symptoms of schizophrenia has also been replicated by antagonism of the NMDA-R by substances such as phencyclidine (PCP) and ketamine [7]